Laboratory for Imaging Physics, Analysis, and Clinical Translation (IMPACT)

The IMPACT lab, led by Grace J. Gang, PhD, is dedicated to developing CT and cone-beam CT imaging technologies guided by a rigorous understanding of imaging science. 

Research areas

Novel imaging techniques for interventional applications

Novel image acquisition and reconstruction techniques for task-driven imaging and non-circular cone-beam CT orbits for metal artifact reduction.

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Spectral imaging

Detector modeling, material decomposition algorithms, and image-quality modeling for imaging systems with photon-counting and multi-layer detectors.

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Deep learning image formation

Algorithms and analysis methods for deep learning reconstruction and post-processing, including approaches that incorporate domain knowledge in learned models.

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Physics-guided radiomics standardization

Methods that use prior knowledge of spatial resolution and noise to remove scanner-dependent variability in radiomics features.

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Image quality & task-driven imaging

Image chain modeling and model observers for subjective image quality assessment.

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Image analysis

Image analysis and quantitative feature extraction, including working-angle prediction for neuro-interventional procedures.

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Leadership

 
Grace J. Gang, PhD Principle Investigator

Dr. Grace J. Gang is an associate professor in the Department of Radiology at the University of Pennsylvania. She received a Bachelor of Applied Science and a PhD in Biomedical Engineering from the University of Toronto. Her work focuses on image-quality modeling, assessment, and optimization for advanced X-ray imaging modalities, spanning X-ray detector physics, image reconstruction, system modeling and optimization, and human visual perception. Dr. Gang has received many awards, including first place in the John R. Cameron Young Investigator Symposium, the AAPM Research Seed Grant, the Moses and Sylvia Greenfield Award, the Jack Fowler Junior Investigator Award (2018), and the John Laughlin Early-Career Scientist Award.

Email Dr. Gang