Focus
Britton Chance Laboratory of Redox Imaging brings together physicists, chemists, biologists, clinicians, and statisticians for cross-disciplinary biomedical imaging studies of the redox status coupled to reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) in conditions such as cancer, aging, and neurodegenerative diseases. We are currently developing optical/NMR imaging and spectroscopic biomarkers for cancer diagnosis, prognosis, and therapeutic response, and understanding the fundamental role of NAD- and FAD-coupled redox state in cancer transformation and progression to metastasis.
Leadership
Laboratory details
Staff
- Yu Wen, PhD
Senior Research Investigator and Lab Manager - Skyler Nova, BS
Lab Technician - David Nelson
Research Specialist
Associated faculty and collaborators
- Kavindra Nath, Ph.D.
- Fernando Arias-Mendoza, MD, PhD
- Julia Tchou, MD, PhD
- Payal Shah, MD
- Saya Jacob, M.D.
- Elizabeth McDonald, M.D., Ph.D.
- Anupma Nayak, MBBS, MD
- Huaqing Zhao, PhD
- Qiuhong He, PhD
Previous members or alumni
- Shoko Nioka, PhD
Senior Research Investigator - Zhenwu Lin, PhD
Research Investigator - Lily Moon
Research Specialist - Jinxia Jiang
Research Specialist - Allison Podsednik
Research Specialist
- Podsednik A, Jacob A, Li LZ, Xu HN. Relationship between optical redox status and reactive oxygen species in cancer cells. React Oxyg Species. 2020;9(26):95–108.
- Wen Y, Xu HN, Privette Vinnedge L, Feng M, Li LZ. Optical redox imaging detects the effects of DEK oncogene knockdown on the redox state of MDA-MB-231 breast cancer cells. Mol Imaging Biol. 2019;21(3):410-416.
- Xu HN, Feng M, Nath K, et al. Optical redox imaging of lonidamine treatment response of melanoma cells and xenografts. Mol Imaging Biol. 2019;21(3):426-435.
- Xu HN, Tchou J, Feng M, Zhao H, Li LZ. Optical redox imaging indices discriminate human breast cancer from normal tissues. J Biomed Opt. 2016;21(11):114003.
- Xu HN, Nioka S, Glickson JD, Chance B, Li LZ. Quantitative mitochondrial redox imaging of breast cancer metastatic potential. J Biomed Opt. 2010;15(3):036010.
- Li LZ, Zhou R, Xu HN, et al. Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci U S A. 2009;106(16):6608-6613.
Lin Z. Li, PhD.
Research Associate Professor
Phone: 215-746-7387
Email: linli@pennmedicine.upenn.edu