Research and clinical trials

Endocrinology Diabetes & Metabolism Research Faculty

• Mona Al Mukaddam, MD, MS
• Anastassia Amaro, MD
• Anne R. Cappola, MD, ScM
• Mitchell A. Lazar, MD, PhD
• Susan J. Mandel, MD, PhD
• David Merrick, MD, PhD
• Michael R. Rickels, MD, MS
• Peter J. Snyder, MD
• Doris A. Stoffers, MD, PhD

Penn diabetes research center

The Penn Diabetes Research Center (DRC) fosters research and training in the areas of diabetes and related endocrine and metabolic disorders. DRC is located in the Smilow Center for Translational Research, which is a component part of a single integrated building providing health services for patients, biomedical research laboratories, and education space.

Visit the Penn Diabetes Research Center

Clinical trials for endocrine disorders and diabetes at Penn

Clinical trials help shape new clinical discoveries that have the potential to become treatments and therapies for endocrine disorders and diabetes.

View a list of active clinical trials for endocrine disorders and diabetes

Institute for diabetes obesity and metabolism at Penn

The Institute for Diabetes Obesity and Metabolism (IDOM) supports and develops successful approaches to the prevention, treatment, and cure of diabetes mellitus and obesity.

Visit the Institute for Diabetes Obesity and Metabolism

Clinical trials

To have your clinical trial included in our list, please complete the Clinical Trial Information Form

Penn Rodebaugh Diabetes Center trials
Andrea Kelly, MD, MSCE & Michael Rickels, MD, MS	Emergence and Progression of Abnormal Glucose Tolerance in Cystic Fibrosis
Ali Naji, MD & Michael Rickles, MD, MS	A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus with Impaired Hypoglycemic Awareness and Severe Hypoglycemia
James Markmann, MD, PhD and Michael Rickels, MD	A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-264 in Subjects With Type 1 Diabetes Mellitus
Rahaf Sultan, MD and Michael Rickels, MD, MS	TZIELD® (teplizumab-mzwv) in Patients with Stage 2 Type |  ClinicalResearch Studies Listing
Michael Rickels, MD, MS	Closed Loop and Education for hypoglycemia Awareness (CLEAR) | Clinical Research Studies Listing
Michael Rickels, MD, MS	A phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes and a low residual β-cell function at baseline
Michael Rickels, MD, MS & Zoltan Arany, PhD	Effect of Branched Chain Amino Acids on Free Fatty Acid-Induced Insulin Resistance in Healthy Adults.
Mark Schutta, MD	Epidemiology of Diabetes Interventions and Complications Study (EDIC STUDY)
Penn Bone Center trials
Mona Al Mukaddam, MD, MS	A Phase 2, two-part, placebo-controlled, parallel-group, double-blind study to assess the efficacy and safety of 2 dosage regimens of oral IPN60130 for the treatment of fibrodysplasia ossificans progressiva in male and female participants 5 years of age and older (FALKON)
Mona Al Mukaddam, MD, MS	Rollover Study; Multicentre, Phase III, Open-label Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years with Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed Study PVO-1A-301 or PVO-1A-202/PVO-1A-204 and May Benefit from Palovarotene Therapy. (PIVOINE)
Mona Al Mukaddam, MD, MS	A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva (PROGRESS)
Felix Wehrli, PhD	Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
Penn Metabolic Medicine trials
Anastastia Amaro, MD	A Prospective, Randomized, Double-Blind, Sham- Controlled, Multi-Center Pivotal Study to Evaluate the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita® System in Subjects with Type 2 Diabetes on Insulin therapy
Kelly Allison, PhD	Meal Timing and Metabolism Study
Zoltan P. Arany, M.D., Ph.D., Michael R. Rickels, MD., MS	Investigation of the Effect of Branched Chain Amino Acids on Fat-Induced Insulin Resistance in Healthy Adults
David Merrick, MD, PhD	Human Metabolic Tissue Bank
Penn Pituitary Center trials
Peter Snyder, MD	A Randomized, Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Paltusotine in Subjects with Acromegaly Treated with Long-acting Somatostatin Receptor Ligands
Penn Thyroid Center trials
Anne Cappola, MD, MS	Ghrelin Plus Resistance Training in Frail Elderly Study