Our faculty lead a broad portfolio of cardiovascular research that spans the spectrum from basic and translational research to clinical science, population science, and health services research. This is accomplished in partnership with multiple institutes and centers throughout the Perelman School of Medicine, most notably the Penn Cardiovascular Institute.
Cardiovascular clinical research unit
The mission of the CCRU is to enhance clinical trial operations, to expand the portfolio of investigational therapy available to patients, and to provide a platform for faculty to execute sponsor-initiated and investigator-initiated clinical science. This mission is accomplished by providing project management, regulatory support, study coordination, and by leveraging resources at Penn and beyond to lead clinical science.
Section Leadership
Kenneth Margulies, MD
Director, Cardiovascular Clinical Research Unit
Professor of Medicine
Ken.Margulies@pennmedicine.upenn.edu
Lindsey Behlman
Associate Director, Cardiovascular Clinical Research Unit
Lindsey.Behlman@pennmedicine.upenn.edu
215-615-2354
Kim Clinton
Associate Director, Cardiovascular Clinical Research Unit
Kimberly.Clinton@pennmedicine.upenn.edu
215-662-2803
Brenda Rynn
Director of Fiscal Operations for Research
Brenda.Rynn@pennmedicine.upenn.edu
215-746-4946
Division of cardiovascular medicine centers
The Penn Center for Quantitative Echocardiography is a state of the art facility dedicated to the efficient and accurate acquisition and quantitation of echocardiographic images and Doppler velocity signals for single- and multi- center clinical trials nationally and internationally. The lab's experience in quantitative echocardiography began in 1979 and our experience as a core lab for large, multi- center clinical trials has resulted in guideline-changing practice in heart failure pharmacologic and device therapy. Most of our work is focused in the field of cardio-oncology, we support research that seeks to understand the connections between cancer treatment and cardiovascular symptoms in order to provide cancer patients with less harmful options. The Center offers state of the art quantitative analyses of 2D and 3D echocardiograms, including detailed measures of cardiac mechanics, remodeling, and function. Dedicated to reproductive, accurate and precise quantitation, we serve as the core lab multiple for NIH, AHA, and industry funded studies.
Section leadership
- Bonnie Ky, MD, MSCE
Founders Associate Professor of Medicine and Epidemiology
Director, Penn Center for Quantitative Echocardiography
Director, Thalheimer Center for Cardio-Oncology
Section faculty and staff
- Frank Silvestry, MD
Associate Professor of Medicine
Associate Chief for Education Cardiovascular Division
Director, Penn Cardiovascular Disease Fellowship
fsilvest@pennmedicine.upenn.edu - Amanda M. Smith, BA, MS
Project Manager
Amanda.Smith4@pennmedicine.upenn.edu - Tenaadam A Tsega, MD
Project Manager
Tenaadam.Tsega@pennmedicine.upenn.edu - Zhen Chen, MD, RDCS
Sonographer
Zhen.Chen@pennmedicine.upenn.edu - Jade Chung, RDCS
Sonographer
Jade.Chung@pennmedicine.upenn.edu - Amber Daniels, BS, RDCS
Sonographer
Amber.Daniels@pennmedicine.upenn.edu - Virginia Englefield, RCS
Sonographer
Virginia.Englefield@pennmedicine.upenn.edu - Megi Sula
Clinical Research Assistant
megi.sula@pennmedicine.upenn.edu - Brenda Rynn
Director of Fiscal Operations for Research
Brenda.Rynn@pennmedicine.upenn.edu - Uma Rao
Grants Manager
Uma.Rao@pennmedicine.upenn.edu
Contact information:
Penn Center for Quantitative Echocardiography
Hospital of the University of Pennsylvania
Rhoads Bldg., Ground Floor
3400 Spruce St.
Philadelphia, PA 19104
Email: EchoCoreLab@pennmedicine.upenn.edu
Phone: 215-349-5753
The Penn Cardiovascular Institute (CVI) is a multi-disciplinary group of scientists dedicated to scientific discoveries and medical breakthroughs in heart and vascular diseases. Penn CVI focuses on fundamental discovery and its translation, which means transforming basic research discoveries to develop breakthrough diagnostics, therapies and clinical devices aimed at cardiovascular disease, the leading killer in the United States.